Together with the facts that a decrease in plasma PAF-AH activity is related to inflammatory responses in humans [27,28,29], PAFR activation or high PAF levels are associated with menstrual pain in primary dysmenorrhea and fibromyalgia in humans [31,32], and an increase in PAF production exacerbates postoperative pain (including neuropathic pain) in mice [15,26], the decrease in PAF-AH activity in plasma caused by the PLA2G7 rs1051931 polymorphism may contribute to acute postoperative pain, including neuropathic pain, in humans through higher plasma levels of PAF. Here, PCLAF is linked to neuropathic pain.