The crucial discrepancies are associated with the extent of accessibility alterations, with Jun proto-oncogene (JUN) (B, D)HIGH, Fos proto-oncogene (FOS) (L1, L2)HIGH, double homeobox 4 (DUX4), KLF transcription factor 5 (KLF5), MYC-associated factor X (MAX)/MYC proto-oncogene (MYC), paired box 6 (PAX6), and peroxisome proliferator-activated receptor gamma (PPARG) suggesting CBD astrocytes, and decreased TFEB and cAMP responsive element-binding protein 1 (CREB1) accessibilities indicative of PSP astrocytes [52]. This evidence concerns the gene DUX4 and supranuclear palsy, progressive, 1.