Furthermore, whole-exome sequencing in a 61-year-old female patient with a clinical manifestation of PSP revealed the E342K variant of MAPT [20], while the homozygosity linked with the MAPT H1 haplotype is considered to be a risk factor for PSP and corticobasal degeneration (CBD) [21]. This evidence concerns the gene MAPT and supranuclear palsy, progressive, 1.