Whole-genome sequencing by Wang et al. found—alongside the genetic loci commonly linked with PSP pathophysiology, such as MAPT, MOBP, STX6, solute carrier organic anion transporter family member 1A2 (SLCO1A2), dual-specificity phosphatase 10 (DUSP10), and SP1 transcription factor (SP1)—signals for apolipoprotein E (APOE), FCH and mu domain-containing endocytic adapter 1 (FCHO1)/MAP1S, kinesin family member 13A (KIF13A), tripartite motif-containing 24 (TRIM24), tenascin XB (TNXB), and ELVOL fatty acid elongase 1 (ELOVL1). Here, SP1 is linked to supranuclear palsy, progressive, 1.