ITGAM and HIV infectious disease: Because CD11b plays a critical role in monocyte migration under both physiological and pathological conditions [41] and is involved in the HIV infection of monocytes/macrophages [42] as well as in proinflammatory cytokine production, the decreased expression of CD11b in LTECs may lead to reduced sensitivity to CD11b-mediated activation, resulting in a lower proinflammatory response [43,44].