The study found that the A/L ratio had a negative relationship with the number of eosinophils in the peripheral blood, proinflammatory cytokines (IL-6, IL-8, and TNF-alpha), and a direct relationship with FEV1 and FVC, which measure how well the lungs are working outside the receptor polymorphism with an A/A genotype, may be linked to a higher risk of getting severe asthma that is difficult to control. Here, TNF is linked to asthma.