Further meta-analysis, including data from 59 studies, also showed that patients with severe asthma are characterized by higher leptin levels compared to controlled asthma (Standard mean difference, SMD 1.638, 95% CI: 0.952–2.323, p < 0.0001), which was more significant for Asian patients (SMD: 2.600, 95% CI: 1.854–3.345, p < 0.0001) [13]. The gene discussed is LEP; the disease is asthma.