FLNC and heart disorder: Furthermore, mutations in non-desmosomal genes, including Transmembrane protein 43—luma (TMEM 43), Phospholamban (PLN), Filamin C (FLNC), Desmin (DES), and LMNA (Lamin A/C), have been identified as contributing to the pathogenesis of heart disease [88] (see Table 2).