DSC2 and heart disorder: Mutations in desmosomal genes have been observed in 50% of patients with arrhythmogenic heart disease, and these are represented by mutations in the genes for Plakophilin C (PKP2), Desmoplakin (DSP), Desmocollin-2 (DSC2), Desmoglein-2 (DSG2), and Plakoglobin (JUP) [88,89].