In various studies, some other variables were associated with a better long-term response, such as sinus rhythm, female sex, non-ischemic etiology of HF, duration of HF symptoms, smaller LA and LV dimensions, milder mitral and tricuspid regurgitation, reduced BNP levels, or creatinine levels [16,17,24,25,26,27]. This evidence concerns the gene NPPB and hydrops fetalis.