As an adjunctive observation, a follicular helper T-cell phenotype has been detected also in MF biopsies with large-cell transformation, while TIA-1, granzyme B, and perforin are positive only in cytotoxic MF or, sometimes, in tumor lesions with variable expression also of CD56, even in some biopsies with conventional CD4 positivity. This evidence concerns the gene CD4 and mycosis fungoides.