In chronic inflammatory diseases, such as rheumatoid arthritis, systemic lupus erythematosus, Behçet’s disease, Kawasaki’s disease, and Sjögren’s syndrome, sCD40L levels have been studied and it has been suggested that they may be associated with the risk of cardiovascular disease [5,6,7,8,9]. The gene discussed is CD40LG; the disease is systemic lupus erythematosus.