INS and type 1 diabetes mellitus: The results of the MVMR analysis demonstrated that, following adjustments for fasting insulin levels, T1D (MVMR-IVW, OR = 1.06, 95% CI 1.02 to 1.10, p = 0.002) and T2D (MVMR-IVW, OR = 1.11, 95% CI 1.05 to 1.17, p < 0.001) exerted significant independent effects on the risk of PE.