MMP12 and colitis: It was also reported that the polysaccharides from Armil-lariella tabescens mycelium might alleviate dextran sulfate sodium-induced colitis symptoms in mice, because the polysaccharides were able to enhance the integrity of colon tissue by up-regulating both mucin-2 and TJ proteins as well as suppressing the MMP12/MLCK/p-MLC2 signaling pathway [35].