This study, along with another, attributed this effect to Sestrins’ support of AKT activity [33,34], potentially via a possible association with mTORC2 via the GATOR2 complex [34], suggesting that while Sestrin–mTORC1 signalling is well defined, their cooperation with mTORC2 could be an important area for further cancer research. Here, AKT1 is linked to cancer.