NFE2L2 and brain injury: In ischemic brain injury, LFHP-1c inhibits microglial activation, attenuates endothelial cell apoptosis, and reduces neuroinflammation through 5′-adenosine monophosphate-activated protein kinase (AMPK) and nuclear factor erythroid 2-like 2 (NRF2, NFE2L2) activation [14,15].