NK cells exert anti-tumour effects through direct cytolytic killing of tumour cells, as well as by mediating immune responses via the release of pro-inflammatory cytokines, such as IFN-γ and TNF, which promote tumour cell apoptosis, suppress angiogenesis, and modulate the recruitment and function of other immune cells in the TME [26,27,28]. This evidence concerns the gene TNF and neoplasm.