MAP1LC3A and colorectal carcinoma: However, as for other cancers, the precise role of autophagy in CRC appears to vary by context, with prior studies reporting conflicting findings regarding the expression and clinical outcomes associated with various autophagy proteins, such as ATG5, Beclin-1, and the autophagosomal marker microtubule-associated protein 1 light chain 3 (LC3) [29,30].