KLRK1-AS1 and neoplasm: Tumor suppressor ncRNA-PEP/MPs: In contrast to oncogenic ncRNA-PEP/MPs, tumor-suppressive ncRNA-MPs like miRNA-PEP133, SP0495, and TP53LC04 enforce strict regulatory controls that maintain cell cycle checkpoints and induce apoptosis in response to genomic stress [39,114,117], often through p53-related pathways.