For example, in certain studies, CD69+ and CD103+ T cells were associated with enhanced cytotoxicity and better outcomes [29,30,31]; contrastingly, others have demonstrated that under chronic antigenic stimulation and within immunosuppressive TMEs, these same markers may be associated with T-cell exhaustion and diminished anti-tumor efficacy [17,32,33,34]. This evidence concerns the gene CD69 and neoplasm.