Analogous to the history of systemic therapies in advanced ccRCC, the prospective trials in papillary RCC initially focused on VEGFR TKI monotherapies, with cabozantinib (inhibitor of MET, AXL, and VEGFR2) outperforming sunitinib (inhibitor of PDGFR, VEGFR1-3, KIT, and RET) in the only direct comparison of these agents [5]. The gene discussed is AXL; the disease is nonpapillary renal cell carcinoma.