BRAF and lung carcinoma: While the combination of dabrafenib and trametinib is recommended in the treatment of BRAF V600E-mutated NSCLC in the main guidelines, in the event of the appearance of a BRAFV600E mutation as a resistance mechanism after osimertinib progression, there is currently disagreement over the best course of action for concurrently addressing BRAF and EGFR in lung cancer.