The CBP/β-catenin antagonist ICG-001, in diffuse intrinsic pontine gliomas, down-regulates genes involved in stemness maintenance (i.e., ID1 and ID3) by targeting SE, yet increase the expression of invasion promoting genes, via p300 recruitment, which can be effectively targeted by JQ-1, a BET inhibitor [206]. The gene discussed is DNER; the disease is diffuse intrinsic pontine glioma.