Introduction of a single oncogenic mutation, without inflammatory insult, only initiate intestinal tumor formation within one of the putative ISC populations (i.e., Lgr5/prominin/Bmi1 positive populations) [84,96,97], and targeting transient amplifying (TA) cells either had no effect or generated only microadenomas [96]. This evidence concerns the gene LGR5 and intestinal neoplasm.