Li X. M. et al. showed that, in CRC, tumor-derived lactate downregulates retinoic acid receptor γ (RARγ) expression in macrophages, which results in upregulation of IL-6 levels in the TME and macrophage tumor-promoting functions via TRAF6-IL-6-STAT3 signaling [24]. Here, STAT3 is linked to neoplasm.