BRCA1 and malignant colon neoplasm: A genome-wide association study (GWAS) has evaluated the association between microRNA (miRNA) expression levels and 327 miRNA-related SNPs and between SNPs and colon cancer risk [53]; the AA genotype of BRCA1 rs8176318 SNP was found to be associated with reduced miRNA expression and also with colon cancer risk (OR 1.31), suggesting that SNP rs8176318 induces thyroid cancer by altering the miRNA–mRNA target interactions.