Unsupervised clustering revealed distinct immune cell populations within the tumor microenvironment, including conventional CD4+ T cells (CD4Tconv), CD8+ T cells (CD8T), exhausted CD8+ T cells (CD8Tex), monocytes/macrophages (Mono/Macro), proliferating T cells (Tprolif), and regulatory T cells (Treg) (Figure 7A). This evidence concerns the gene CD8A and neoplasm.