IL15 and neoplasm: Li et al. have extended these observations through their study of NK-CAR cells engineered to express CAR19 alone, IL-15 alone, and CAR19 and IL-15: the overexpression of CAR 19 and IL-15 resulted in the generation of CAR-NK cells with increased proliferation, enhanced antitumor activity, higher metabolic fitness, improved glycolytic activity, higher MYC expression, improved persistence and survival in vivo, and longer-lasting anti-tumor response [79].