Wojtukiewicz et al. [15] presented a comprehensive update on the impact of TFPI2 on tumor progression and metastasis, while Kobayashi et al. [16] explored the association between elevated serum TFPI2 levels and prognosis in ovarian and endometrial cancers, proposing that TFPI2 may paradoxically function as a tumor-promoting factor in these malignancies. Here, TFPI2 is linked to neoplasm.