It is overexpressed in lobular breast carcinoma, hepatocellular carcinoma, and melanoma [15,25,159,160], where it enhances invasion via the TF–factor VIIa complex and supports angiotropism and vasculogenic mimicry (VM), aiding tumor perfusion and correlating with poor prognosis in several cancers [154,160,161]. This evidence concerns the gene TF and melanoma.