EZH2 and neoplasm: In glioblastoma, lncRNA AGAP2-AS1 recruits lysine-specific histone demethylase 1 (LSD1) and enhancer of zeste homolog 2 (EZH2) to the TFPI2 promoter, leading to H3K27me3 and DNMT1-mediated methylation, silencing TFPI2 and promoting tumor progression [126,127].