Spindle cell/sclerosing rhabdomyosarcomas typically harbor certain genomic alterations, including rearrangements involving TFCP2, VGLL2, NCOA2, CITED2, TEAD1, and SRF, as well as the MYOD1 p.L122R mutation [17,18,19]. The gene discussed is VGLL2; the disease is rhabdomyosarcoma.