Examples include TRA::MTCP1 for T-PLL, TYK2 rearrangement for T-cell lymphomas; CCND1 and CCND2 rearrangement with IGK and IGL in mantle cell lymphoma; MYC rearrangements and hyperdiploidy in multiple myeloma (Table 1). This evidence concerns the gene TYK2 and plasma cell myeloma.