We had previously demonstrated that CRC tumors with both low total VCAN and high αDPEAAE staining intensity (termed VCAN proteolytic predominant, or VPP) demonstrated the greatest CD8+ T cell infiltration [17], and we discovered that recombinant Vkine has independent immunostimulatory activity in vitro [16,17]. Here, CD8A is linked to colorectal carcinoma.