On the other hand, germline mutations in CDK4 or in the DNA repair genes BAP1 (BRCA1 associated protein-1), APEX1 (apopurinic/apurinic-endodeoxyribonuclease 1) or even TERT-linked gene (TERT, POT1, ACD, TERF2IP) mutations may also predispose to melanoma. This evidence concerns the gene BAP1 and melanoma.