CDKN2A and melanoma: However, not only oncogenic mutations occur in melanomas, but also those of suppressor genes, with a similar frequency (10–15%): TP53 (tumor protein p53), NF1 (neurofibromin 1), CDKN2A (cyclin-dependent kinase inhibitor 2 A), PTEN (phosphatase and tensin homolog) [5].