Among other PFs identified through MGPT in cancer predisposition genes related to the patient’s phenotype, we included PVs in MMR genes detected in three patients with Lynch syndrome, biallelic PVs of MUTYH in a patient with attenuated adenomatous polyposis, and a PV in CDKN2A in a patient with a family history of melanoma. The gene discussed is CDKN2A; the disease is melanoma.