The latter category includes low-penetrance PVs (lowPVs) and heterozygous PVs in recessive genes (hetPVs), for which there is no consensus regarding their association with cancer risk in the heterozygous state (e.g., MUTYH, NTHL1, NBN, RAD50, MRE11, and others) [10]. The gene discussed is MUTYH; the disease is cancer.