Data indicate that ANXA1 is also involved in bidirectional crosstalk between macrophages and tumor cells, promoting M2-polarized TAM aggregation [32,33], and is involved in the activation of multiple immunosuppressive pathways, including PD-L1 signaling in glioblastoma [34], breast cancer [25,35], and other malignancies [30]. This evidence concerns the gene CD274 and breast carcinoma.