IFNG and cancer: ANXA1-high tumors were enriched in immunology-related pathways such as chemokine receptor–ligand interactions and interferon gamma and interleukin signaling, whereas ANXA1-low tumors were enriched in pathways of cancer cell biology, such as the signaling of activated point mutants of FGFR1 and recycling of bile acids and salts (Figure 2B).