We also aimed to reveal the functional role of ANXA1, by evaluating its direct effect on cancer cell growth and its effects on chemosensitivity and gene expression changes in mesenchymal markers, metabolic markers, dominant molecular subtype-specific transcriptional drivers, and immune-relevant molecules using in vitro short hairpin (sh) RNA-based gene silencing on non-NE SCLC cell lines. The gene discussed is ANXA1; the disease is small cell lung carcinoma.