Furthermore, we assessed the direct impact of ANXA1 on cancer cell behavior through in vitro experiments using short hairpin RNA (shRNA)-based gene silencing in non-NE SCLC cell lines H1048 (POU2F3+), SW1271 (YAP1+), and H841 (YAP1+), which all show high levels of ANXA1 expression according to cell line data. The gene discussed is POU2F3; the disease is cancer.