Separately, AML with CK, MK, inv(3)(q21.3q26.2) or t(3;3)(q21.3;q26.2)/GATA2, MECOM(EVI1), or TP53 Mut have been proposed into this category based on their significantly worse complete remission (CR) rates, event-free survival (EFS), and OS [6]. Here, RUNX1 is linked to acute myeloid leukemia.