Based on the analyses, the authors suggest modification of the current guidelines for the management of patients with NF1-OPG, including the abandonment of contrast administration in control magnetic resonance imaging (MRI), reducing the frequency of MRI in patients with isolated involvement of the initial nerve segment by the tumor, and a cautious approach to patients with comorbidities such as delayed psychomotor development or epilepsy. Here, NF1 is linked to neoplasm.