In the same manner, p62 contributes to later tumorigenesis by interacting with kelch-like ECH-associated protein 1/nuclear factor erythroid 2-related factor 2 (Nrf2), tumor necrosis factor receptor-associated factor 6 (TRAF6), receptor-interacting serine/threonine-protein kinase-1 (RIPK1), mammalian mitogen-activated protein kinase (MAPK), and regulatory-associated protein of mTOR (RAPTOR) to protect cells from cell stress, allowing for greater cancer cell survival and growth as well as chemotherapy resistance [15,16]. This evidence concerns the gene NFE2L2 and cancer.