ALKBH5 and nonpapillary renal cell carcinoma: RNA-seq results showed that FTO and ALKBH5 expression levels were significantly reduced in ccRCC patients (Figure 4b), and based on a log2FC of <−1.5 and >1.5 and a q-value < 0.05, 8640 genes were shown to be significantly downregulated and 2229 genes significantly upregulated in ccRCC patients.