These rearrangements involve in-frame fusions with over 100 partners; the most common KMT2A-r cases found in adult AML are t(9;11) KMT2A-MLLT3, t(6;11) KMT2A-MLLT4, t(11;19) KMT2A-ELL, and in-frame partial tandem duplications (PTD) (Table 1). Here, AFDN is linked to acute myeloid leukemia.