CD8A and breast cancer: Other sex related mechanisms that might be associated with altered CD8 T cell function include tumor mutational burden and neoantigen load [160].These findings underscore the clinical relevance of the sex-specific differences in CD8+ T cell immunity, as a pathway to developing personalized and more effective treatment strategies for BC:Targeting the androgen signaling pathway: therapeutic strategies that attenuating androgen signaling could enhance CD8+ T cell activity and improve anti-tumor immunity.