INS and coronary artery disorder: The clinical case studies and epidemiological observations that hypertension (HT) and coronary artery disease (CAD) occur more frequently in men than in premenopausal women [180–186] have led to the dogmatic view that TES and other androgens exert deleterious effects on the heart and vasculature and worsen the development of CVD in men, in part by exacerbating risk factors such as blood pressure (BP), body fat composition, insulin resistance, and serum lipid profiles [187–189].