Our current study demonstrates that the LV myocardium of patients with concomitant DM and AS exhibits a pronounced inflammatory response characterized by elevated levels of pro-inflammatory mediators (e.g. HMGB1, calprotectin) and receptors (TLR2, TLR4, RAGE) as well as enhanced NLRP3 inflammasome activation, which is correlated with increased interleukin release. This evidence concerns the gene HMGB1 and diabetes mellitus.