The augmented NLRP3 inflammasome complex was associated with significantly elevated levels of IL-1 (Fig. 2B; AS−DM: mean ± SEM: 11.61 ± 0.4117 pg/mL; AS+DM: 15.46 ± 0.6483 pg/mL), IL-6 (Fig. 2C; AS−DM: mean ± SEM: 2.375 ± 0.2073 pg/mL; AS+DM: 3.203 ± 0.2590 pg/mL), and IL-18 (Fig. 2D; AS−DM: mean ± SEM: 12.79 ± 0.9408 pg/mL; AS+DM: 16.20 ± 0.8725 pg/mL) in diabetic AS patients compared to non-diabetic AS patients. Here, NLRP3 is linked to aortic valve stenosis.