Furthermore, downstream components of the cardiac inflammasome, including nuclear factor kappa B (NF-κB; Fig. 1G; AS−DM: mean ± SEM: 10.77 ± 0.8726 ng/mL; AS+DM: 13.77 ± 0.7853 ng/mL) and NOD-like receptor protein 3 (NLRP3; Fig. 1H; AS−DM: mean ± SEM: 12.00 ± 0.4961 pg/mL; AS+DM: 14.19 ± 0.7383 pg/mL), were also significantly increased in diabetic AS compared to non-diabetic AS patients. Here, NLRP3 is linked to diabetes mellitus.