For example, SE heterogeneity analysis has identified SOX10 as the master regulator of the RTK I subtype in glioblastoma [22], HLX as the master regulator of the Group 3 subtype in medulloblastoma, and LMX1A as the master regulator of the Group 4 subtype in medulloblastoma [16]. The gene discussed is HLX; the disease is medulloblastoma.