STAT3 and JAK2 are also involved in numerous cardiovascular diseases, including diabetic cardiomyopathy (Ji et al. 2024), atherosclerosis (Guo et al. 2024), pathological myocardial hypertrophy and fibrosis (Zhang et al. 2019), and lipopolysaccharide-induced myocardial injury (Fang and Guan 2024). The gene discussed is JAK2; the disease is cardiac hypertrophy.