CD8A and autoimmune disease: Despite some evidence of local CD8 + cytotoxic T lymphocyte infiltration in vitiligo, pathological biopsies usually show sparse or sometimes absent local lymphocyte infiltration (Picardo et al. 2015), which is markedly different from the pattern observed in common clinical autoimmune diseases, for example, cutaneous lupus erythematosus (Niebel et al. 2023), where lymphatic infiltration is typically present in lesions.