NLRP3 and neoplasm: For example, miR- 223 - 3p targets NLRP3 to regulate cartilage degeneration [22]; in breast cancer, miR- 223 - 3p induces NLRP3 inflammasome inactivation, inhibits tumor growth, and enhances antitumor immunity [23]; miR- 223 - 3p also regulates NLRP3 expression in immune cells [24].