GSDMD and gastroesophageal reflux disease: The results revealed a significant decrease in miR- 223 - 3p expression during the development of reflux esophagitis in HET- 1 A cells (Fig. 2A, P < 0.001), accompanied by significant increases in the expression levels of caspase- 1, NLRP3, and GSDMD (Fig. 2A-B, P < 0.05).