NLRP3 and gastroesophageal reflux disease: While most studies show that high expression of miR- 223 - 3p inhibits NLRP3 inflammasome activation, a recent study indicated that in a gastric acid reflux esophagitis rat model, miR- 223 - 3p expression was significantly higher in reflux esophagitis tissues compared to controls, and its expression gradually decreased as reflux esophagitis progressed from the acute to the chronic stage [29].