However, miR- 223 - 3p mediates the transition from chronic inflammation to gastric carcinogenesis through the NF-κB signaling pathway, due to the identification of a conserved NF-κB binding site within the promoter region of miR- 223 - 3p, and miR- 223 has no effect on the expression of NF-κB in the gastric cancer cells [45]. Here, NFKB1 is linked to gastric cancer.