The NLRP3 inflammasome plays a crucial role in various inflammation-related diseases, such as arthritis, Alzheimer's disease, and inflammatory bowel disease [30–32], while miR- 223 - 3p has been shown to inhibit its expression by targeting NLRP3 mRNA [33]. The gene discussed is NLRP3; the disease is early-onset autosomal dominant Alzheimer disease.