Increased release of pro-inflammatory factors (IL-17, IFN-γ) disrupts the balance of flora, interferes with the bone marrow hematopoietic microenvironment, affects the normal function of hematopoietic stem cells, and ultimately triggers hematological toxicity, resulting in anemia, leukopenia, and other symptoms. This evidence concerns the gene IFNG and Decreased total leukocyte count.