ESR1 and neoplasm: Clinical tumor category cT, age, and presence of multiple tumors had significant influence on treatment timing (p = 0.004, p = 0.002, and p = 0.016, respectively), whereas race, ethnicity, estrogen receptor, and grading were not associated with timing of treatment (p = 0.894, p = 0.074, p = 0.240, and p = 0.169, respectively) (Table 3).