The activation of the NLRP3 inflammasome is involved in several pathological processes and conditions, including obesity, diabetes mellitus, gout, rheumatoid arthritis, tumors, subarachnoid hemorrhage, neurodegenerative disorders, Crohn's disease, chronic obstructive pulmonary disease, asthma, cryopyrin-associated periodic syndrome, geographic atrophy, and sepsis [121]. The gene discussed is NLRP3; the disease is obesity due to melanocortin 4 receptor deficiency.