In lung cancer, particularly in lung adenocarcinomas, alveolar type II (ATII) cells expressing surfactant protein C, Club cells expressing CC10 (also known as uteroglobin, encoded by SCGB1A1) and bronchoalveolar stem cells (BASC) positive for CC10 and SPC can serve as tumor cell-of-origin12–14. Here, SCGB1A1 is linked to lung cancer.