In the field of lung cancer, driving Cre-recombinase expression under the control of specific promotors such as SFTPC for targeting ATII cells, SCGB1A1 for targeting Club cells, and calcitonin gene-related peptide (CGRP) to target neuroendocrine pulmonary cells, will likely minimize the off-target effect on the non-epithelial cell compartments in the lung. The gene discussed is SCGB1A1; the disease is lung cancer.