APOE and early-onset autosomal dominant Alzheimer disease: Looking at important genetic factors, we observed variants located in the APOE locus, including rs449647 and rs7412. Furthermore, the variant rs157580, located in the TOMM40 locus, and rs60049679, located in the APOC1 locus, which make up the well-known Alzheimer’s disease risk gene cluster, APOE-TOMM40-APOC145.