Fibroblasts accumulated in TF under MTC conditions initiated substantial recruitment and adhesion pathways of N1-TANs, including CXCL2-CXCR2, COL1A2-CD44, and so on, while cleared N2-TANs via CXCL12-CXCR4. Here, CXCR4 is linked to medullary thyroid gland carcinoma.