TP53 and myelodysplastic syndrome: Our cohort had baseline mutational profiles typical of MDS/CMML/AML67 with the most frequent mutations occurring in TET2 (10/28; 35.7%), RUNX1 (10/28; 35.7%), SRSF2 (9/28, 32.1%), and TP53 (8/28; 28.6%) (Supplementary Fig. 10a, b).