TNF and metastatic malignant neoplasm in the lymph nodes: By analyzing the protein expression of METTL1, WDR4, and TNF-α in PTC tumor tissues, we found that PTC tissues from patients with lymph node metastasis had higher METTL1, WDR4, and TNF-α expression than those from patients without lymph node metastasis did (Fig. 7a, b).